Avandia, DRUG CLASS AND MECHANISM: Rosiglitazone is an oral drug that reduces the amount of sugar (glucose) in the blood. It is used for treating patients with type 2 diabetes and is in a class of anti-diabetic drugs called thiazolidinediones. The other member of this class is pioglitazone (Actos). Insulin is a hormone produced by the pancreas that is important for controlling the levels of glucose in the blood. Insulin stimulates the cells of the body to remove glucose from the blood and thereby lowers the level of glucose in the blood. Patients with type II diabetes cannot make enough insulin. As a result, the cells in their bodies do not remove enough glucose from the blood, and the level of glucose rises. Rosiglitazone often is referred to as an “insulin sensitizer” because it attaches to the insulin receptors on cells throughout the body and causes the cells to become more sensitive (more responsive) to insulin and remove more glucose from the blood. At least some insulin must be produced by the pancreas in order for rosiglitazone to work). Rosiglitazone was approved by the FDA on May 28, 1999.

GENERIC AVAILABLE: No

PRESCRIPTION: Yes

PREPARATIONS: Tablets: 2, 4, and 8 mg.

STORAGE: Tablets should be kept at room temperature, 15-30 C (59-86 F).

PRESCRIBED FOR: Rosiglitazone, combined with diet, exercise, weight control, and cessation of smoking is used for treating type II diabetes. Rosiglitazone may be used alone or in combination with other types of anti-diabetic drugs such as metformin (Glucophage) or sulfonylureas as well as insulin. Since it requires naturally-secreted insulin to be effective, rosiglitazone is not recommended for use in type I diabetes where the amount of insulin is very low or absent.

DOSING: Rosiglitazone may be taken once or twice daily, with or without meals. Daily doses range from 4 to 8 mg either with or without other antidiabetic medications. Studies do not demonstrate additional effects when more than 8mg per day are taken.

DRUG INTERACTIONS: Rifampin decreases the blood concentration of rosiglitazone by increasing its breakdown in the liver. Therefore, use of rifampin may decrease the effect of rosiglitazone.

Gemfibrozil (Lopid) increases the concentration of rosiglitazone in the blood by reducing its breakdown. Therefore, rosiglitazone may increase the side effects of rosiglitazone.

PREGNANCY: There are no adequate studies of rosiglitazone in pregnant women.

NURSING MOTHERS: It is unknown if rosiglitazone is secreted in breast milk. Therefore, the safety of rosiglitazone to nursing infants also is unknown.

SIDE EFFECTS AND PRECAUTIONS: The most common side effects seen with rosiglitazone alone or in combination with metformin are upper respiratory tract infection, headache, back pain, hyperglycemia, fatigue, sinusitis, diarrhea, and hypoglycemia. Rosiglitazone has been shown to cause mild to moderate accumulation of fluid (edema) and can lead to heart failure. Patients who already have heart failure may develop worsening symptoms with rosiglitazone. In addition, anemia may occur with rosiglitazone alone or combined with metformin. Rosiglitazone also causes increasing amounts of weight gain with increasing doses.

WELLINGTON: Pakistan Beats Kiwis by 141 Runs to Level Series, Pakistan thrashed New Zealand by 141 runs in second cricket Test match to level the series by 1-1 here at Wellington on Sunday.

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New Zealand were all-out for 263 runs in their second innings falling short of 141 runs of 405-run target.

Muhammad Asif claimed five wickets in second innings, 9 wickets in match and was awarded man of the match.

New Zealand, chasing an unlikely 405 to win, were bowled out for 263, Mohammad Asif doing most of the damage with 5-67.

Ross Taylor top-scored for the Black Caps with 97.

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Pakistan, who lost the first Test by 32 runs, led by 165 in the first innings in this Test after bowling New Zealand out for 99.

But they then teased the home side with their own batting collapses before reasserting control of the second Test on day three yesterday.

Their second innings folded between lunch and tea for 239 – seven wickets toppled for 42 runs – although it barely offered a glimmer of hope to a New Zealand side who managed only 99 in their first innings.

The Kiwis were left chasing 405 to win and by stumps were 3-70, still 335 adrift.

The only consolation was Ross Taylor’s continued presence at the crease.

If New Zealand are to complete the fourth highest successful run chase in Test history and eclipse their previous best pursuit of 5-324 against Pakistan at Christchurch in 1994, much will rely on New Zealand’s only in-form batsman.

Taylor was not out 15 and Peter Fulton has 12, although both had lives on 13 and three respectively as Pakistan’s catching woes continue.

With two days remaining, yet again the exploits of a weary bowling attack – deprived of first-Test hero Shane Bond – appear destined to go unrewarded.

Chris Martin and Iain O’Brien added four wicket hauls to Daryl Tuffey and Daniel Vettori’s identical returns in the first innings.

Martin improved from 0-44 to 4-52 as Pakistan deteriorated, O’Brien bristled with aggression throughout to record four for 66 – sterling service considering the duo barely had their feet up between bowling assignments after New Zealand’s first innings lasted only 36.5 overs.

Medium pacer Grant Elliott also made a belated and inspired arrival in the 72nd over, having Shoaib Malik and Kamran Akmal caught behind with his fifth and sixth deliveries.

Martin also found himself on a hat-trick with the second new ball by ending captain Mohammad Yousuf’s stout resistance after a failed leg before wicket appeal was overturned. Tailender Danish Kaneria then snicked to Taylor at slip.

Yousuf produced the only bedrock innings of the day — and one New Zealand’s remaining batsmen will need to emulate if Friday’s third test in Napier is not to be a decider.

Yousuf took his time making 83 from 200 deliveries, a top score and 30th test fifty made between the 17th and 86th overs.

With the benefit of a 229-run advantage when play began, Yousuf and Misbah-ul-Haq were in no hurry.

Since combining late yesterday they added 77 for the third wicket in 35 overs at a snail paced 2.20 runs per over.

O’Brien was instrumental in accelerating Pakistan’s scoring rate. Misbah’s demise caught at the wicket for 33 was the catalyst for the continuation of Umar Akmal’s stunning debut series.

Only five boundaries were recorded in the 23 overs before the 19-year-old arrived and instantly set about mangling Daniel Vettori’s figures.

The New Zealand captain conceded just 21 runs from his first 17 overs; Umar then proceeded to crack 27 from Vettori’s next four through a trio of boundaries, brace of sixes and three singles.

Umar passed fifty for the third time in his four-test career in just 32 balls though his audacity got the better of him a ball later when a lofted drive was collected by Vettori retreating at deep mid-off.

He thudded his pad in disgust but still has the consolation of 302 runs in the series at 75.50.

The name Omer Nadeem may not ring too many bells among the larger audience, but the fact of the matter is that this guy has been around long enough to work with some of the major music acts of Pakistan these days including Atif Aslam.
Although fame has eluded him from time to time he is now ready to expose his real talent and take the level up a notch.
It was when he was 12 that his interest in music began to increase. He was friends with Haider Haleem at the time and Goher Mumtaz would come to Haider’s place to give him guitar lessons. In such circumstances Omer was, more or less, a self taught guitarist, his own passion driving him to observe and learn what he can by himself.

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Biography Of Omer Nadeem

King Brothers, King brothers, then 12 and 13-years-old, were convicted nearly a decade ago as adults of beating their father to death with a baseball bat while he slept. While their motives are unclear, speculation is that they were under the influence of their neighbor, a convicted sex offender. He was initially acquitted but then convicted of being an accessory after the fact.

The brothers, now released from prison, are speaking out about their life before and after incarceration in an interviews with NBC.

Millions of people will be searching Obama school speech, Obama school speech time, Obama school speech transcript, Obama school speech text, Obama speeches video to watch  Obama School Speech Video. President Obama’s speech on education addresses to school students across the United States.

Obama’s school speech to children, here’s video below of President Obama’s school speech that was given today, September 8, 2009, at Noon ET from CNN.  or at http://www.whitehouse.gov/live/

Embedded video from CNN Video

Melanie Oudin Photos, Melanie Oudin in the quarter finals at the U.S. Open on Wednesday at Arthur Ashe Stadium. It will be the first appearance at this level for both players.

Aerosmith guitarist Joe Perry has said that he is heartbroken at the idea of not completing their current tour.

The gig ended after the lead vocalist Steven Tyler got injured, when he fell from the stage during a show in South Dakota.

“We still don””t know if we””re going to keep the tour up or what. It”’’s breaking my heart,” Contactmusic quoted him as saying.

Tyler broke his shoulder and suffered minor head and neck injuries after he toppled mistiming a dance step.

He is presently being treated at the local Rapid City Regional Hospital.

The band has already postponed the scheduled concert in Winnipeg, Canada to allow him to heal.

However, they have 18 dates scheduled on their summer tour, with their final performance due to take place in Detroit, Michigan on 16 September.

The group has been drawn back due to similar problems earlier as well.

Tyler opted to cancel many shows after he suffered a leg injury, while bandmate Brad Whitford had to skip touring duties after undergoing surgery for a burst blood vessel.

Also, their planned tour in 2008 and dates earlier this year were postponed to allow Perry to recover from a knee surgery.

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Aerosmith star Joe Perry heartbroken at prospect of axing current tour

Announcing the return of the hottest Khatron Ka Khiladi ever, the heart-stoppingly handsome and macho Akshay Kumar to the screen this September with his bevy of thirteen beauties and death defying dares is a sizzling new music trailer set to the beats of the treacherous South African wilderness.

Akshay’’s sexy sena in this most revolutionary reality show India has ever witnessed will see hotties like Bruna Abdalah, Sushma Reddy, Carol Gracias, Jesse Randhawa, Mandira Bedi, Nauheed Cyrusi, Rosa Catalano, Rupali Ganguly, Sonika Kaliraman, Shonali Nagrani, Pia Trivedi, Shveta Salve and Anushkha Manchanda.

Back on the scene with a power packed punch of adrenaline and oozing attitude is the ”Level 2” on COLORS with a music trailer that defines the action – laced rhythm of the show.

What begins with the beating of the ngoma drums soon moves on to acquire the urgency that precedes action, the slow rise of adrenaline all set to a foot tapping tune with lyrics that inspire josh and reflect the frantic pace of the show.

The music trailer is a prelude to the biggest action-packed reality show on television through music that conveys a heightened level of risk and the urgency attached to it.

The music trailer further also does the brilliant job of announcing the names of the thirteen screen goddesses competing against each other, whose names appear in an intelligently seamless rap-like rendition.

The eclectic music composition has been created by the talented Salim Sulieman remixed by Amartya Rahut and lending his voice for the track is Neeraj Shridhar.

With a season that promises a lot more sizzling drama and never-before-seen action and stunts; these thirteen beauties will be facing their worst fears coming alive.

The ladies” man Akshay Kumar will be acting as more than just an anchor to the show. He will be the guide, the friend and the much needed courage booster these beauties will be in desperate need of.

Announcing the names of the girls and the music trailer, Ashvini Yardi, Programming head of COLORS said, “For a show that has already shattered all preconceived notions of fear and has turned thirteen glam dolls into daredevils, the season two had to be something that took the viewers” experience to the next level. Keeping this in mind, we decided to come up with a music trailer to announce the launch of the Level 2 of Khatron Ke Khiladi – a song that embodies the dangerous rhythm vibrating through each challenge and that echoes the racing heart of every beauty facing that challenge. This is the level two of attitude and action and India better be ready for a never-before-felt adrenaline shot!”

On this occasion Deepak Dhar MD Endemol India said, “Coming from the success of Khatron ke Khiladi season 1, we at Endemol India have risen to give the viewers a Bigger and Bolder thrill and changed the face of reality television. With our expert stunt team we have broken all the barriers of fear. This year our chosen location was South Africa ,Cape town where the new contestants challenged their fears and raw nature at its wildest. Experience the beauty of fear and enjoy true entertainment in this season’’s Fear Factor Extreme – Khatron Ke Khiladi Level 2″

The show, Fear Factor Khatron Ke Khiladi – shot entirely in South Africa’’s picturesque city of Cape Town features some of the most exhilarating stunts ever seen on television set against the backdrop of a region that is home to the most varied flora and fauna to be found on the face of this earth.

The death-defying stunts have been shot in the most breathtaking locations in the Mother City, as Cape Town is fondly called.

Expect the unexpected when thirteen beauties battle each other, the nature and themselves to overcome their biggest, deepest, darkest and creepiest fears!

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Khatron Ke Khiladi is back with 13 new girls and level 2 of attitude!